[dmwg] [physics] Corona research > Identifying SARS-CoV-2 related coronaviruses in Malayan pangolins (Nature, 30.03.2020) {01}

[IOP Scientific Activities]

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Identifying SARS-CoV-2 related coronaviruses in Malayan pangolins (Nature, 
30.03.2020)
Tommy Tsan-Yuk Lam, Marcus Ho-Hin Shum, Hua-Chen Zhu, Yi-Gang Tong, Xue-Bing 
Ni, Yun-Shi Liao, Wei Wei, William Yiu-Man Cheung, Wen-Juan Li, Lian-Feng 
Li, Gabriel M. Leung, Edward C. Holmes, Yan-Ling Hu, Yi Guan
The ongoing outbreak of viral pneumonia in China and beyond is associated 
with a novel coronavirus, SARS-CoV-21. This outbreak has been tentatively 
associated with a seafood market in Wuhan, China, where the sale of wild 
animals may be the source of zoonotic infection2. Although bats are likely 
reservoir hosts for SARS-CoV-2, the identity of any intermediate host that 
might have facilitated transfer to humans is unknown. Here, we report the 
identification of SARS-CoV-2-related coronaviruses in Malayan pangolins 
(Manis javanica) seized in anti-smuggling operations in southern China. 
Metagenomic sequencing identified pangolin-associated coronaviruses that 
belong to two sub-lineages of SARS-CoV-2-related coronaviruses, including 
one that exhibits strong similarity to SARS-CoV-2 in the receptor-binding 
domain. The discovery of multiple lineages of pangolin coronavirus and their 
similarity to SARS-CoV-2 suggests that pangolins should be considered as 
possible hosts in the emergence of novel coronaviruses and should be removed 
from wet markets to prevent zoonotic transmission.
Nature 2020
https://dx.doi.org/10.1038/s41586-020-2169-0






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